Issue 2, 2010

Synthesis of tetraketones in water and under catalyst-free conditions

Abstract

A simple, environmentally friendly, tandem Knoevenagel condensation and Michael addition procedure is reported. The reactions between cyclic-13-diketones and a variety of aldehydes were carried out in water to afford tetraketones (64–99%). In this green synthetic protocol, the solvent water itself catalysed the reaction by hydrogen bonding, thus avoiding the use of any other catalysts to make the work up procedure easier.

Graphical abstract: Synthesis of tetraketones in water and under catalyst-free conditions

Supplementary files

Article information

Article type
Communication
Submitted
13 Jul 2009
Accepted
17 Nov 2009
First published
09 Dec 2009

Green Chem., 2010,12, 216-219

Synthesis of tetraketones in water and under catalyst-free conditions

J. Yu, L. Wang, J. Liu, F. Guo, Y. Liu and N. Jiao, Green Chem., 2010, 12, 216 DOI: 10.1039/B913816A

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