Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 2, 2008
Previous Article Next Article

An alternative method for the regio- and stereoselective bromination of alkenes, alkynes, toluene derivatives and ketones using a bromide/bromate couple

Author affiliations

Abstract

Mixtures of NaBr and NaBrO3 in two different ratios have been used for highly stereoselective bromination of alkenes and alkynes, and regioselective bromine substitution at the α-carbon of ketones and at the benzylic position of toluene derivatives. The reactions were conducted in an aqueous acidic medium under ambient conditions. The solid reagents were prepared from the intermediate obtained in the “cold process” of bromine manufacture and are stable, non-hazardous and inexpensive to prepare. This procedure provides an efficient and practical alternative to conventional procedures using liquid bromine directly or indirectly.

Graphical abstract: An alternative method for the regio- and stereoselective bromination of alkenes, alkynes, toluene derivatives and ketones using a bromide/bromate couple

Back to tab navigation

Supplementary files

Article information


Submitted
10 Sep 2007
Accepted
16 Nov 2007
First published
03 Dec 2007

Green Chem., 2008,10, 232-237
Article type
Paper

An alternative method for the regio- and stereoselective bromination of alkenes, alkynes, toluene derivatives and ketones using a bromide/bromate couple

S. Adimurthy, S. Ghosh, P. U. Patoliya, G. Ramachandraiah, M. Agrawal, M. R. Gandhi, S. C. Upadhyay, P. K. Ghosh and B. C. Ranu, Green Chem., 2008, 10, 232
DOI: 10.1039/B713829F

Social activity

Search articles by author

Spotlight

Advertisements