Issue 8, 2007
From the journal:

Green Chemistry

Effect of ionic liquids on human colon carcinoma HT-29 and CaCo-2 cell lines

Raquel F. M. Frade,a   Ana Matias,a   Luis C. Branco,bc   Carlos A. M. Afonsoc  and  Catarina M. M. Duarte*a  

* Corresponding authors

a Nutraceuticals and Delivery Laboratory, ITQB/IBET, Aptd. 12, Oeiras, Portugal
E-mail: rfrade@itqb.unl.pt, amatias@itqb.unl.pt, cduarte@itqb.unl.pt
Fax: +351 21 442 11 61
Tel: +351 21 446 97 27

b REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal
E-mail: luis_c_branco@yahoo.com

c Centro de Química Física Molecular, Complexo-1, Instituto Superior Técnico, Av. Rovisco Pais, Lisboa, Portugal
E-mail: carlosafonso@ist.utl.pt
Fax: +351 21 8419785
Tel: + 351 21 846 4455/7

Abstract

The toxicity of ionic liquids, involving different classes of cations and different types of anions, was evaluated by a colorimetric assay with 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) in two colon carcinoma HT-29 and CaCo-2 cell lines. Confluent CaCo-2 cells can undergo spontaneously an enterocytic differentiation and represent a good in vitro model of normal human intestinal epithelium. Ionic liquids are highly promising due to their low vapour pressures, however, toxicity evaluation of these ionic liquids is of great importance to assess the risk of these ionic liquids to humans and the environment.

Graphical abstract: Effect of ionic liquids on human colon carcinoma HT-29 and CaCo-2 cell lines

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Article information

DOI
https://doi.org/10.1039/B617526K
Article type
Paper
Submitted
01 Dec 2006
Accepted
28 Feb 2007
First published
22 Mar 2007

Green Chem., 2007,9, 873-877

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Effect of ionic liquids on human colon carcinoma HT-29 and CaCo-2 cell lines

R. F. M. Frade, A. Matias, L. C. Branco, C. A. M. Afonso and C. M. M. Duarte, Green Chem., 2007, 9, 873 DOI: 10.1039/B617526K

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