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Issue 9, 2020
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Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2

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Abstract

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread around the world at an unprecedented rate. In the present study, 4 marine sulfated polysaccharides were screened for their inhibitory activity against SARS-CoV-2, including sea cucumber sulfated polysaccharide (SCSP), fucoidan from brown algae, iota-carrageenan from red algae, and chondroitin sulfate C from sharks (CS). Of them, SCSP, fucoidan, and carrageenan showed significant antiviral activities at concentrations of 3.90–500 μg mL−1. SCSP exhibited the strongest inhibitory activity with IC50 of 9.10 μg mL−1. Furthermore, a test using pseudotype virus with S glycoprotein confirmed that SCSP could bind to the S glycoprotein to prevent SARS-CoV-2 host cell entry. The three antiviral polysaccharides could be employed to treat and prevent COVID-19.

Graphical abstract: Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2

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Article information


Submitted
01 Aug 2020
Accepted
24 Aug 2020
First published
24 Aug 2020

Food Funct., 2020,11, 7415-7420
Article type
Communication

Inhibitory activities of marine sulfated polysaccharides against SARS-CoV-2

S. Song, H. Peng, Q. Wang, Z. Liu, X. Dong, C. Wen, C. Ai, Y. Zhang, Z. Wang and B. Zhu, Food Funct., 2020, 11, 7415
DOI: 10.1039/D0FO02017F

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