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Issue 10, 2020
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γ-Aminobutyric acid (GABA) activates neuronal cells by inducing the secretion of exosomes from intestinal cells

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Abstract

The oral administration of γ-aminobutyric acid (GABA) has been shown to affect brain functions. However, the molecular mechanisms underlying GABA-induced gut–brain interactions have not yet been fully elucidated. As the blood–brain barrier is impermeable to GABA, we hypothesized that the gut–brain interaction might be stimulated by some secretory factors derived from the gut. Then we focused on exosomes as a secretory mediator. In the present study, we investigated whether exosomes derived from GABA-treated intestinal cells activate neuronal cells. Our results revealed that secretory factors derived from GABA-treated intestinal cells (Caco-2) activated neuronal cells (SH-SY5Y). Further investigation revealed that exosomes derived from GABA-treated Caco-2 cells were responsible for activating the SH-SY5Y cells. These results suggested that GABA-activated intestinal cells induce the secretion of exosomes that activate neuronal cells. MicroRNAs in the exosomes derived from GABA-treated intestinal cells may play a key role in the activation of neuronal cells.

Graphical abstract: γ-Aminobutyric acid (GABA) activates neuronal cells by inducing the secretion of exosomes from intestinal cells

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Article information


Submitted
07 May 2020
Accepted
11 Sep 2020
First published
17 Sep 2020

Food Funct., 2020,11, 9285-9290
Article type
Paper

γ-Aminobutyric acid (GABA) activates neuronal cells by inducing the secretion of exosomes from intestinal cells

R. Inotsuka, K. Uchimura, A. Yamatsu, M. Kim and Y. Katakura, Food Funct., 2020, 11, 9285
DOI: 10.1039/D0FO01184C

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