Jump to main content
Jump to site search

Issue 9, 2020
Previous Article Next Article

Vitamin D and non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Author affiliations

Abstract

The results of randomized controlled trials (RCTs) investigating supplemental vitamin D on aminotransferases and cardio-metabolic risk factors in subjects with non-alcoholic fatty liver disease (NAFLD) have been inconsistent. The present study aimed to quantitatively evaluate whether supplementation with vitamin D has beneficial effects in treatment of NAFLD. A systematical literature search was performed with Cochrane Library, PubMed, Scopus databases and Web of Science up to June 2020. The mean changes in alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), and triglyceride (TAG) were calculated as standard mean difference (SMD) using a random-effects model. Pre-specified subgroup and univariate meta-regression analyses were performed to identify the sources of heterogeneity. Ten trials with a total of 544 NAFLD subjects were included for data synthesis. The summary estimates indicated that supplemental vitamin D significantly reduced the levels of serum/plasma fasting glucose (−0.22; 95%CI: −0.39, −0.04), insulin (−0.68; 95%CI: −1.22, −0.14) and HOMA-IR (−1.32; 95%CI: −2.30, −0.34), and marginally reduced the ALT (−0.18; 95%CI: −0.39, 0.04) and TAG (−10.38; 95%CI: −21.09, 0.34) levels. However, the pooled effect did not support that supplemental vitamin D was beneficial for concentrations of AST, TC, HDL-C and LDL-C. The present study provides substantial evidence that supplemental vitamin D has favorable effects on glycemic control and insulin sensitivity in NAFLD patients. Vitamin D could be as an adjuvant pharmacotherapy of NAFLD.

Graphical abstract: Vitamin D and non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

Back to tab navigation

Supplementary files

Article information


Submitted
28 Apr 2020
Accepted
25 Aug 2020
First published
25 Aug 2020

Food Funct., 2020,11, 7389-7399
Article type
Review Article

Vitamin D and non-alcoholic fatty liver disease: a meta-analysis of randomized controlled trials

X. Guo, C. Wang, T. Yang, S. Li, K. Li and D. Li, Food Funct., 2020, 11, 7389
DOI: 10.1039/D0FO01095B

Social activity

Search articles by author

Spotlight

Advertisements