Issue 9, 2019

Chicoric acid improves neuron survival against inflammation by promoting mitochondrial function and energy metabolism

Abstract

Chicoric acid (CA), a major nutraceutical component of a typical Mediterranean vegetable, chicory, possesses excellent antioxidant and anti-inflammatory bioactivities. This work aimed to elucidate the effects of CA on neuron survival against inflammation and the underlying molecular mechanisms. Results demonstrated that CA promoted SH-SY5Y cells’ autophagic vesicle formation, up-regulated autophagic elongation phase related gene expressions, and inhibited apoptosis stimulated by microglial conditioned culture medium (MCM). In addition, CA significantly improved mitochondrial function and regulated redox homeostasis related signaling pathways such as MAPKs and PI3K/AKT. MCM with CA notably increased the expressions of PGC-1α, SIRT1 and enhanced the phosphorylation of AMPK, promoting energy metabolism. On the other hand, the underlying mechanisms of the intervention of CA in MCM-induced cell apoptosis were partly due to its direct protective effect on SH-SY5Y cells and inhibition of microglial inflammatory factor release. This establishes a theoretical foundation for neuro-nutrition intervention studies of natural functional food components, and provides new clues for developing health foods containing CA.

Graphical abstract: Chicoric acid improves neuron survival against inflammation by promoting mitochondrial function and energy metabolism

Article information

Article type
Paper
Submitted
01 Jul 2019
Accepted
28 Aug 2019
First published
10 Sep 2019

Food Funct., 2019,10, 6157-6169

Chicoric acid improves neuron survival against inflammation by promoting mitochondrial function and energy metabolism

Q. Liu, J. Fang, P. Chen, Y. Die, J. Wang, Z. Liu and X. Liu, Food Funct., 2019, 10, 6157 DOI: 10.1039/C9FO01417A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements