Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 5, 2019
Previous Article Next Article

Anti-obesity potential of rare sugar d-psicose by regulating lipid metabolism in rats

Author affiliations


D-Psicose is a new-generation sugar substitute with a low calorie count and can still offer the desirable sweetness. The objective of this study was to investigate the antiobesity potential of D-psicose and the possible mechanism using Wistar rats as the animal model. The animals were divided into five groups and supplemented with diets containing 5% of different carbohydrates, such as glucose, fructose, cellulose, D-psicose, and a control diet, for 4 weeks. After sacrifice, blood lipid profile, tissue morphology, and related genes participating in lipid metabolism were analyzed. The results indicated that the supplementation by D-psicose leads to minimum fat accumulation in rats when compared with the other carbohydrates. The blood lipid profile and antioxidative activity of the rat were also improved. D-Psicose can regulate lipid metabolism by increasing the lipid-metabolism-related enzymes such as SDH in serum and liver and HL in the liver. D-Psicose can prevent fat accumulation by suppressing the expression of lipogenesis-related gene ACCα and hepatic fatty acid uptake gene (FAS and SREBP-1c), while stimulating the expression for fatty-acid-oxidation-related gene including AMPK2α, HSL, and PPARα. In conclusion, D-psicose can be considered to be a healthy alternative to traditional sweeteners.

Graphical abstract: Anti-obesity potential of rare sugar d-psicose by regulating lipid metabolism in rats

Back to tab navigation

Article information

31 May 2018
29 Oct 2018
First published
09 Nov 2018

Food Funct., 2019,10, 2417-2425
Article type

Anti-obesity potential of rare sugar D-psicose by regulating lipid metabolism in rats

J. Chen, W. Huang, T. Zhang, M. Lu and B. Jiang, Food Funct., 2019, 10, 2417
DOI: 10.1039/C8FO01089G

Social activity

Search articles by author