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Issue 8, 2018
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Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

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Abstract

Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously that hydroxytyrosol inhibits angiogenesis both in vitro and in vivo. In the present study, we evaluate the anti-angiogenic potential of five hydroxytyrosol derivatives. Three of these derivatives contain a nitro group and they exhibit a much weaker effect than hydroxytyrosol in the tubule formation assay on Matrigel and therefore were not studied further. In contrast, both hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether show more potent inhibitory effects than hydroxytyrosol in both the in vitro tubule formation assay on Matrigel and the in vivo chorioallantoic membrane assay. Additionally, these three compounds had slight pro-apoptotic effects and decreased matrix metalloproteinase-2 levels in cell extracts.

Graphical abstract: Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

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Article information


Submitted
08 Jun 2018
Accepted
30 Jun 2018
First published
04 Jul 2018

Food Funct., 2018,9, 4310-4316
Article type
Paper

Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

A. López-Jiménez, E. Gallardo, J. L. Espartero, A. Madrona, A. R. Quesada and M. Á. Medina, Food Funct., 2018, 9, 4310
DOI: 10.1039/C8FO01140K

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