Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 10, 2018
Previous Article Next Article

Characterization of proteins with Siaα2-3/6Gal-linked glycans from bovine milk and role of their glycans against influenza A virus

Author affiliations

Abstract

The bovine milk proteins have a wide range of functions, but the role of the attached glycans in their biological functions has not been fully understood yet. Here, the glycopatterns of whole bovine milk proteins were analyzed using lectin microarrays. Then, the proteins with Siaα2-3/6Gal-linked glycans were isolated and characterized. The roles of Siaα2-3/6Gal-linked glycans of the isolated proteins were assessed by inhibiting viral activity against influenza A viruses (IAV). In total, there were 69 sialylated proteins to be identified and annotated. The sialylated proteins have the ability to inhibit the attachment of IAV mimics to MDCK cells; however, the role of inhibition was abolished when the sialic acid moieties were destroyed. The results demonstrate that the sialic acid moieties of proteins could serve as competitive substrates to disturb the viral attachment to cell surface receptors. Our findings will help to assess the potential application of sialylated glycoproteins in bovine milk against IAV.

Graphical abstract: Characterization of proteins with Siaα2-3/6Gal-linked glycans from bovine milk and role of their glycans against influenza A virus

Back to tab navigation

Publication details

The article was received on 14 May 2018, accepted on 14 Aug 2018 and first published on 16 Aug 2018


Article type: Paper
DOI: 10.1039/C8FO00950C
Citation: Food Funct., 2018,9, 5198-5208

  •   Request permissions

    Characterization of proteins with Siaα2-3/6Gal-linked glycans from bovine milk and role of their glycans against influenza A virus

    H. Yu, Y. Zhong, Z. Zhang, X. Liu, K. Zhang, F. Zhang, J. Zhang, J. Shu, L. Ding, W. Chen, H. Du, C. Zhang, X. Wang and Z. Li, Food Funct., 2018, 9, 5198
    DOI: 10.1039/C8FO00950C

Search articles by author

Spotlight

Advertisements