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Issue 9, 2016

The effect of sun-dried raisins (Vitis vinifera L.) on the in vitro composition of the gut microbiota

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Abstract

Modulation of the human gut microbiota has proven to have beneficial effects on host health. The aim of this work was to evaluate the effect of sun-dried raisins (SR) on the composition of the human gut microbiota. A full model of the gastrointestinal tract, which includes simulated mastication, a dynamic gastric model, a duodenal model and a colonic model of the human large intestine, was used. An increase in the numbers of bifidobacteria and lactobacilli was observed by plate-counting in response to the addition of either SR or FOS after 8 and 24 h fermentation. A significant decrease in Firmicutes and Bacteroidetes was observed in SR samples after 8 and 24 h fermentation. FOS resulted in the greatest production of short chain fatty acids. Sun-dried raisins demonstrated considerable potential to promote the colonization and proliferation of beneficial bacteria in the human large intestine and to stimulate the production of organic acids.

Graphical abstract: The effect of sun-dried raisins (Vitis vinifera L.) on the in vitro composition of the gut microbiota

Supplementary files

Article information


Submitted
30 Jul 2016
Accepted
13 Aug 2016
First published
16 Aug 2016

This article is Open Access

Food Funct., 2016,7, 4048-4060
Article type
Paper

The effect of sun-dried raisins (Vitis vinifera L.) on the in vitro composition of the gut microbiota

G. Mandalari, S. Chessa, C. Bisignano, L. Chan and A. Carughi, Food Funct., 2016, 7, 4048 DOI: 10.1039/C6FO01137C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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