Jump to main content
Jump to site search

Issue 10, 2016
Previous Article Next Article

Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo

Author affiliations

Abstract

Uric acid is a metabolite obtained from purine by xanthine oxidase activity (XO) and high levels of serum uric acid leads to hyperuricemia and gout. Mesona procumbens Hemsl. has been used as a healthy beverage and a traditional remedy. In this study, the hypouricemic effects of M. procumbens extracts were evaluated in vitro and in vivo. The 50% ethanol extract of M. procumbens (EE50) showed the strongest inhibitory effect on monosodium urate (MSU)-induced XO activity in THP-1 cells. However, the phenolics and flavonoids in EE50 may not serve as inhibitors of XO. EE50 prevented an increase in the serum uric acid level in potassium oxonate (PO)-challenged ICR mice and streptozocin (STZ)-induced SD rats. EE50 down-regulated STZ-induced liver XO activity, and it restored renal OAT1 and urate transporter expression. STZ-induced renal interleukin-1β (IL-1β) and the tumor necrosis factor-α (TNF-α) level were inhibited by EE50 treatment. EE50 exhibits the hypouricemic effect via down-regulation of XO activity, suggesting that EE50 has potential to improve hyperuricemia and its complications.

Graphical abstract: Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Jun 2016, accepted on 06 Sep 2016 and first published on 29 Sep 2016


Article type: Paper
DOI: 10.1039/C6FO00822D
Food Funct., 2016,7, 4239-4246

  •   Request permissions

    Hypouricemic effects of Mesona procumbens Hemsl. through modulating xanthine oxidase activity in vitro and in vivo

    J. Jhang, J. Ong, C. Lu, C. Hsu, J. Lin, J. Liao and G. Yen, Food Funct., 2016, 7, 4239
    DOI: 10.1039/C6FO00822D

Search articles by author

Spotlight

Advertisements