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Issue 3, 2016

Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis

Author affiliations

Abstract

The parasitic fungus, Paecilomyces sinensis, is used to produce Cordyceps materials as a succedaneum of natural Cordyceps sinensis (C. sinensis) in China. In this work, a glycopeptide (CPS-II) was isolated and purified from Paecilomyces sinensis. The result of HPLC indicated that CPS-II was a glycopeptide. The estimated average molecular weight of CPS-II was 2 × 106 Da. FTIR, methylation, periodate oxidation, Smith degradation, 1H NMR, 13C NMR and CD were used for its structural analysis. The glycopeptide CPS-II was mainly composed of (1 → 3), (1 → 4) connected glucose and galactose as the backbone, there are (1 → 2,3,6) connected glucose, (1 → 3,6) connected mannose, and (1 → 6) connected galactose. Cell proliferation assay and morphological observations indicated that in a certain range of concentrations and time, CPS-II can significantly improve the proliferation activity of RAW264.7 cells.

Graphical abstract: Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis

Article information


Submitted
23 Jan 2016
Accepted
14 Feb 2016
First published
16 Feb 2016

Food Funct., 2016,7, 1593-1600
Article type
Paper

Structural analysis and immunostimulatory activity of glycopeptides from Paecilomyces sinensis

Z. Zhu, M. Meng, H. Sun, Y. Li, N. Yu and Y. Zhang, Food Funct., 2016, 7, 1593 DOI: 10.1039/C6FO00089D

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