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Issue 4, 2016
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Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

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Abstract

Polysaccharides from Ganoderma lucidum (GLPs) have been taken as effective supplements by both healthy people and cancer patients for many years. However, this short survey indicates that instead of inhibiting cancer cell growth, both submerge-cultured intracellular GLP and fruiting body GLP can stimulate the growth of human carcinoma cell lines lacking functional p53, such as HCT-116 p53−/−, Saos-2, H1299, HL-60, MDA-MB-157. Conversely, the two GLPs inhibit all other assayed cells with functional p53. These results could be an alert since mutational inactivation of the tumor suppressor protein p53 is the most frequent genetic alteration found in human tumors.

Graphical abstract: Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

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Publication details

The article was received on 29 Dec 2015, accepted on 02 Mar 2016 and first published on 04 Mar 2016


Article type: Communication
DOI: 10.1039/C5FO01628B
Citation: Food Funct., 2016,7, 1872-1875

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    Inhibitor or promoter? The performance of polysaccharides from Ganoderma lucidum on human tumor cells with different p53 statuses

    J. Zhang, J. Chen, X. Wang, Y. Xia, S. W. Cui, J. Li and Z. Ding, Food Funct., 2016, 7, 1872
    DOI: 10.1039/C5FO01628B

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