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Issue 3, 2016
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Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice

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Abstract

In this paper, we have investigated the hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein (SSP) on streptozocin (STZ)-induced diabetic IRC mice. The effects of SSP on the body weight (BW), fasting blood glucose (FBG) levels, serum lipids, inflammatory factors and insulin (SIN) levels of normal and diabetic mice have been investigated. SSP has been shown to reduce insulin resistance (IR) and control the effects of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and nuclear factor-κ-gene binding (NF-κB). In addition, this paper further validates the hypoglycemic and anti-inflammatory effects of seabuckthorn procyanidins (SPR) and seabuckthorn polysaccharides (SPO) in diabetic mice and the experimental results were consistent with previous studies. Moreover, results from animal experiments showed that SSP has a significant hypoglycemic and anti-inflammatory effect as evidenced by the lower BW, FBG levels, SIN and lipid contents of diabetic mice treated with SSP compared to the diabetic control mice.

Graphical abstract: Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice

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Article information


Submitted
23 Dec 2015
Accepted
12 Feb 2016
First published
16 Feb 2016

Food Funct., 2016,7, 1610-1615
Article type
Paper

Hypoglycemic and anti-inflammatory effects of seabuckthorn seed protein in diabetic ICR mice

H. Yuan, X. Zhu, W. Wang, L. Meng, D. Chen and C. Zhang, Food Funct., 2016, 7, 1610 DOI: 10.1039/C5FO01600B

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