Jump to main content
Jump to site search

Issue 11, 2015
Previous Article Next Article

The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

Author affiliations

Abstract

We studied the short-term antihypertensive effect of flavan-3-ols (−)-epicatechin, (+)-catechin and (−)-catechin, in spontaneously hypertensive rats (SHR). Plasma metabolites and the corresponding plasma antioxidant capacity were determined. All the assayed flavan-3-ols decreased systolic blood pressure (SBP) in SHR. Their antihypertensive effects were less pronounced than that of Captopril (50 mg kg−1) and were not shown in normotensive Wistar-Kyoto rats. 6 mg kg−1 (−)-epicatechin caused the maximum decrease in SBP. The maximum effects of the catechin monomers were observed post-administration of 0.5 mg kg−1 of flavan-3-ols, (−)-catechin being the least effective among the three assayed compounds. Glucuronide and methyl glucuronide metabolites were obtained in the flavan-3-ol treated SHR, but it was not possible to relate the antihypertensive effect of the assayed flavan-3-ols with a concrete plasma metabolite or with their antioxidant effect. In conclusion, the studied flavan-3-ols could be responsible for the antihypertensive effect of cocoa products.

Graphical abstract: The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

Back to tab navigation

Article information


Submitted
14 May 2015
Accepted
29 Jul 2015
First published
07 Aug 2015

This article is Open Access

Food Funct., 2015,6, 3479-3489
Article type
Paper
Author version available

The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

M. Quiñones, M. Margalef, A. Arola-Arnal, B. Muguerza, M. Miguel and A. Aleixandre, Food Funct., 2015, 6, 3479
DOI: 10.1039/C5FO00547G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements