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Issue 3, 2015
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Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury

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Abstract

Gastrointestinal mucositis induced by chemotherapy is associated with alterations of intestinal barrier function due to the potential damage induced by anti-cancer drugs on the epithelial cells. Goblet cells, an important epithelial lining in the intestine, contribute to innate immunity by secreting mucin glycoproteins. Employing a mouse model of chemotherapy induced intestinal mucosal immunity injury by cyclophosphamide, we demonstrated for the first time that polysaccharide from the ink of Ommastrephes bartramii (OBP) enhanced Cyto18, which is a mucin expression in goblet cells. The up-regulation of mucins by OBP relied on the augmented quantity of goblet cells, but not on the changes in the ultrastructure of endoplasmic reticulum (ER). Our results may have important implications for enhanced immunopotentiation function of functional OBP on intestinal mucosal immunity against intestinal disorders involving inflammation and infection.

Graphical abstract: Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury

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Article information


Submitted
25 Dec 2014
Accepted
26 Jan 2015
First published
27 Jan 2015

Food Funct., 2015,6, 981-986
Article type
Paper
Author version available

Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury

T. Zuo, L. Cao, C. Xue and Q. Tang, Food Funct., 2015, 6, 981 DOI: 10.1039/C4FO01191K

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