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Issue 4, 2015
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Roles of proanthocyanidin rich extracts in obesity

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Abstract

Obesity is a multifactorial disorder involving an abnormal or excessive amount of body fat. Obese people have a very high probability of developing metabolic syndrome, a condition in which cholesterol, lipid, and glucose levels rise, causing diabetes and heart disease. From the point of view of energy balance, the main contributors to obesity are excessive energy intake, inadequate energy expenditure and metabolic malfunctions. For this reason, health organisations are working to implement policies and plans to promote healthy eating and active living. However, these measures have not yet proven sufficient to combat this worldwide epidemic; therefore, drugs and bioactive compounds are being investigated to complement the existing strategies. In the present review, we discuss the available data regarding the modulation of obesity by proanthocyanidin rich extracts. Because studies with human subjects are very scarce, we focus on studies using laboratory animals. The results of in vitro studies are included because, although they cannot be directly extrapolated to the biological effects of proanthocyanidin, they can reveal some mechanisms of action.

Graphical abstract: Roles of proanthocyanidin rich extracts in obesity

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Article information


Submitted
13 Nov 2014
Accepted
22 Jan 2015
First published
11 Feb 2015

This article is Open Access

Food Funct., 2015,6, 1053-1071
Article type
Review Article

Roles of proanthocyanidin rich extracts in obesity

M. J. Salvadó, E. Casanova, A. Fernández-Iglesias, L. Arola and C. Bladé, Food Funct., 2015, 6, 1053 DOI: 10.1039/C4FO01035C

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