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Issue 3, 2015
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The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice

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Abstract

The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol glycosides and purified from unripe Jindai-soybean (Edamame) leaves in C57BL/6J mice. High fat-fed mice treated with 0.15% dietary KG for 92 days had reduced body weight, adipose tissue and TG levels compared to the high fat-fed control group. KG-treatment also decreased fasting blood glucose, serum HbA1c (hemoglobin A1c) levels and improved insulin resistance. Gene expression analysis of the liver showed that KG decreased peroxisome proliferator-activated receptor (PPAR-γ) and sterol regulatory element-binding protein (SREBP-1c) expression. These results suggest that KG reduced the accumulation of adipose tissue, improving hyperlipidemia as well as diabetes in obese mice by increasing lipid metabolism through the downregulation of PPAR-γ and SREBP-1c. Thus, KG may have an anti-obesity and anti-diabetic potential.

Graphical abstract: The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice

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Article information


Submitted
19 Sep 2014
Accepted
02 Jan 2015
First published
05 Jan 2015

Food Funct., 2015,6, 834-841
Article type
Paper
Author version available

The anti-obesity and anti-diabetic effects of kaempferol glycosides from unripe soybean leaves in high-fat-diet mice

Y. Zang, L. Zhang, K. Igarashi and C. Yu, Food Funct., 2015, 6, 834
DOI: 10.1039/C4FO00844H

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