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Issue 3, 2015
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Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats

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Abstract

In this paper, the effect and mechanism of Salicornia bigelovii Torr. plant salt (SPS) on blood pressure in Sprague Dawley (SD) rats were investigated. The results showed that the edible salt induced hypertension, but the SPS did not. Organ indices and Hematoxylin-Eosin (HE) staining analysis indicated that SPS had a protective effect on the kidney and liver. In comparison with the edible salt-treated group, nitric oxide (NO) content, angiotensin-II (Ang-II) and endothelin-1 (ET-1) levels in the serum of the SPS-treated group had no obvious changes, but serum creatinine concentration significantly decreased. Moreover, superoxide dismutase (SOD) and Na+-K+-ATPase activity increased while malondialdehyde (MDA) content decreased in the SPS-treated group. In conclusion, a long-term high salt intake could lead to hypertension. SPS, as a salt substitute, could increase the body's antioxidant ability to protect the kidney and liver from the damage caused by a high salt intake and effectively avoid the occurrence of hypertension.

Graphical abstract: Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats

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Supplementary files

Article information


Submitted
09 Sep 2014
Accepted
13 Jan 2015
First published
14 Jan 2015

Food Funct., 2015,6, 920-926
Article type
Paper

Effect and mechanism of Salicornia bigelovii Torr. plant salt on blood pressure in SD rats

S. Zhang, M. Wei, C. Cao, Y. Ju, Y. Deng, T. Ye, Z. Xia and M. Chen, Food Funct., 2015, 6, 920 DOI: 10.1039/C4FO00800F

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