Jump to main content
Jump to site search

Issue 11, 2014
Previous Article Next Article

Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα signalling activation

Author affiliations

Abstract

A high-fat (HF) diet increases lipid storage and oxidative stress in mouse liver and this process seems to be mediated by Peroxisome Proliferator-Activated Receptor α (PPARα). In this study we evaluated the protective effect of cocoa against hepatic steatosis induced by a HF diet. The HF diet down-regulated PPARα expression and turned off PPARα-signalling, deregulated the β-oxidation (β-Ox) system and catalase (CAT) activity, increased fat storage, reduced expression of enzymatic activity involved in oxidative defence in the liver and doubled the weight gain per calorie consumed compared to animals under the normal diet. In contrast, cocoa improved hepatic β-Ox, activated PPARα-signalling and up-regulated both gene and protein expression of SOD1. Moreover, when co-administered with the HF diet, cocoa treatment counteracted lipid storage in the liver, improved the lipid-metabolizing activity and oxidative stress defences and normalized the weight gain per calorie consumed.

Graphical abstract: Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα signalling activation

Back to tab navigation

Publication details

The article was received on 14 Jul 2014, accepted on 16 Aug 2014 and first published on 18 Aug 2014


Article type: Paper
DOI: 10.1039/C4FO00616J
Food Funct., 2014,5, 2931-2939

  •   Request permissions

    Cocoa protective effects against abnormal fat storage and oxidative stress induced by a high-fat diet involve PPARα signalling activation

    M. Fidaleo, A. Fracassi, A. Zuorro, R. Lavecchia, S. Moreno and C. Sartori, Food Funct., 2014, 5, 2931
    DOI: 10.1039/C4FO00616J

Search articles by author

Spotlight

Advertisements