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Issue 12, 2014
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Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats

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Abstract

The protective effects of total saponins from Rosa laevigata Michx fruit (RLTS) in high-fat diet (HFD)-induced rats were investigated. The results showed that oral administration of RLTS attenuated hepatic steatosis, significantly reduced the levels of body weight, alanine transaminase, aspartate transaminase, total cholesterol, total triglyceride, free fatty acids, low density lipoprotein, blood glucose, insulin and malondialdehyde, and increased high density lipoprotein and glutathione levels compared with the model group. Further investigations showed that RLTS affected fatty acid synthesis, fatty acid β-oxidation, fatty acid ω-oxidation, total cholesterol and triglyceride metabolism and synthesis. Moreover, the extract obviously suppressed HFD-induced oxidative stress and inflammation. These results suggest that RLTS should be developed to be one functional food or health product against non-alcoholic fatty liver disease (NAFLD) in the future.

Graphical abstract: Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats

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Publication details

The article was received on 07 Jun 2014, accepted on 15 Sep 2014 and first published on 19 Sep 2014


Article type: Paper
DOI: 10.1039/C4FO00491D
Food Funct., 2014,5, 3065-3075

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    Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats

    D. Dong, Y. Qi, L. Xu, L. Yin, Y. Xu, X. Han, Y. Zhao and J. Peng, Food Funct., 2014, 5, 3065
    DOI: 10.1039/C4FO00491D

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