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Issue 10, 2014
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Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling

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Abstract

Quercetin, a bioflavonoid found in plant foods, has a wide range of therapeutic effects. In order to examine the therapeutic potential of quercetin in teratocarcinoma, we used the human teratocarcinoma cell line NT2/D1 as an in vitro model. We have shown that quercetin inhibits the proliferation, adhesion and migration of NT2/D1 cells and downregulates the expression of pluripotency factors SOX2, Oct4 and Nanog. Our results further suggest that the anticancer effect of quercetin against human teratocarcinoma cells is mediated by targeting the canonical Wnt signaling pathway. Quercetin antagonized the Wnt/β-catenin signaling pathway in NT2/D1 cells by inhibiting β-catenin nuclear translocation and the consequent downregulation of β-catenin-dependent transcription. These data suggest that quercetin as a potent inhibitor of Wnt signaling may be an effective therapeutic agent in cancers with aberrant activation of the Wnt pathway.

Graphical abstract: Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling

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Publication details

The article was received on 03 Jun 2014, accepted on 31 Jul 2014 and first published on 31 Jul 2014


Article type: Paper
DOI: 10.1039/C4FO00484A
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Citation: Food Funct., 2014,5, 2564-2573

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    Quercetin reduces pluripotency, migration and adhesion of human teratocarcinoma cell line NT2/D1 by inhibiting Wnt/β-catenin signaling

    M. Mojsin, J. M. Vicentic, M. Schwirtlich, V. Topalovic and M. Stevanovic, Food Funct., 2014, 5, 2564
    DOI: 10.1039/C4FO00484A

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