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Issue 6, 2014
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Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid

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Abstract

Soy lipophilic protein nanoparticles (LPP), which present a novel delivery vehicle for conjugated linoleic acid (CLA), were fabricated by ultrasonication of the soy lipophilic protein (LP), which exhibits unique characteristics including a high loading capacity, oxidation protection and a sustained releasing profile in vitro for CLA. The CLA-loaded LPP exhibited a mean diameter of 170 ± 0.63 nm and a loading capacity of 26.3 ± 0.40% (w/w). A coating of sodium caseinate (SC) on the surface improved the colloidal stability of the CLA-loaded LPP. This encapsulation conferred protection against the oxidation of CLA, by which the head space-oxygen consumption and hydrogen peroxide value were obviously decreased in comparison with the SC-encapsulated CLA and CLA alone. The delivery system enables a sustained releasing profile of CLA in a simulated gastrointestinal tract (GIT). These findings illustrate that the LPP could act as an effective delivery device for CLA, which could provide oxidation stability and a sustained release property.

Graphical abstract: Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid

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Article information


Submitted
15 Oct 2013
Accepted
25 Feb 2014
First published
26 Feb 2014

Food Funct., 2014,5, 1286-1293
Article type
Paper

Soy lipophilic protein nanoparticles as a novel delivery vehicle for conjugated linoleic acid

Z. Gao, L. Zhu, X. Yang, X. He, J. Wang, J. Guo, J. Qi, L. Wang and S. Yin, Food Funct., 2014, 5, 1286
DOI: 10.1039/C3FO60497G

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