Jump to main content
Jump to site search

Volume 179, 2015
Previous Article Next Article

Urea homogeneous nucleation mechanism is solvent dependent

Author affiliations

Abstract

The composition of the mother phase plays a primary role in crystallization processes, affecting both crystal nucleation and growth. In this work, the influence of solvents on urea nucleation has been investigated by means of enhanced sampling molecular dynamics simulations. We find that, depending on the solvent, the nucleation process can either follow a single-step or a two-step mechanism. While in methanol and ethanol a single-step nucleation process is favored, in acetonitrile a two-step process emerges as the most likely nucleation pathway. We also find that solvents have a minor impact on polymorphic transitions in the early stages of urea nucleation. The impact of finite size effects on the free energy surfaces is systematically considered and discussed in relation to the simulation setup.

Back to tab navigation

Associated articles

Article information


Submitted
25 Nov 2014
Accepted
09 Jan 2015
First published
09 Jan 2015

Faraday Discuss., 2015,179, 291-307
Article type
Paper
Author version available

Urea homogeneous nucleation mechanism is solvent dependent

M. Salvalaglio, M. Mazzotti and M. Parrinello, Faraday Discuss., 2015, 179, 291
DOI: 10.1039/C4FD00235K

Social activity

Search articles by author

Spotlight

Advertisements