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Volume 166, 2013
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Self-assembled core–shell micelles from peptide-b-polymer molecular chimeras towards structure–activity relationships

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Abstract

The aim of this contribution is to design, produce and characterize size-tuneable core–shell micelles from amphiphilic Tat-b-poly(trimethylene carbonate) (Tat-b-PTMC) molecular chimeras, and to explore their biological properties. Because the extensive characterization of nanomaterials is a pre-requisite to understand and rationalize their ensuing properties, we present a detailed description of Tat-b-PTMC micelles thanks to light scattering, AFM imaging and small angle neutron scattering analyses. In vitro, Tat-b-PTMC micelles were found to be rapidly and efficiently internalized by HeLa cells, with cellular uptake kinetics being mostly related to Tat peptide content and, to a lesser extent, to nanoparticle size. We also demonstrated that, after a first membrane-binding step, Tat-b-PTMC micelles were taken up by cells via an energy-dependent endocytotic process.

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Article information


Submitted
03 Jun 2013
Accepted
27 Jun 2013
First published
28 Jun 2013

Faraday Discuss., 2013,166, 83-100
Article type
Paper

Self-assembled core–shell micelles from peptide-b-polymer molecular chimeras towards structure–activity relationships

C. Drappier, H. Oliveira, O. Sandre, E. Ibarboure, S. Combet, E. Garanger and S. Lecommandoux, Faraday Discuss., 2013, 166, 83
DOI: 10.1039/C3FD00098B

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