Jump to main content
Jump to site search

Issue 2, 2016
Previous Article Next Article

Role of the capping agent in the interaction of hydrophilic Ag nanoparticles with DMPC as a model biomembrane

Author affiliations

Abstract

The interaction of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) Langmuir monolayers as a model biomembrane with small silver nanoparticles (AgNPs) similar in size but coated with different capping molecules such as citrate (CIT-AgNPs) and 4-mercaptobenzoic acid (MBA-AgNPs), both negatively charged at physiological pH, is studied using a multi-technique approach. Both CIT-AgNPs and MBA-AgNPs expose carboxyl groups and have similar zeta potentials, but differ in the aliphatic or aromatic nature of the capping agent. Results show that AgNPs exhibit quite different behaviors: CIT-AgNPs weakly adsorb on DMPC, while MBA-AgNPs irreversibly adsorb on the interface and remain there upon monolayer compression. It is also shown that there is a cooperative effect of many ligands in the interactions between MBA-AgNPs and DMPC, as MBA molecules in solution are unable to strongly adsorb on the phospholipid monolayer surface. We propose an explanation based on the surface charge density and on the chemical nature of the capping molecule based on XPS studies and on DFT calculations.

Graphical abstract: Role of the capping agent in the interaction of hydrophilic Ag nanoparticles with DMPC as a model biomembrane

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Jan 2016, accepted on 11 Mar 2016 and first published on 14 Mar 2016


Article type: Paper
DOI: 10.1039/C6EN00016A
Environ. Sci.: Nano, 2016,3, 462-472

  •   Request permissions

    Role of the capping agent in the interaction of hydrophilic Ag nanoparticles with DMPC as a model biomembrane

    J. V. Maya Girón, R. V. Vico, B. Maggio, E. Zelaya, A. Rubert, G. Benítez, P. Carro, R. C. Salvarezza and M. E. Vela, Environ. Sci.: Nano, 2016, 3, 462
    DOI: 10.1039/C6EN00016A

Search articles by author

Spotlight

Advertisements