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Issue 8, 2008
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Simultaneous determination of p-arsanilic acid and roxarsone in feed by liquid chromatography-hydride generation online coupled with atomic fluorescence spectrometry

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Abstract

A novel, simple and sensitive liquid chromatography-hydride generation online coupled with atomic fluorescence spectrometry (LC-HG-AFS) method was developed for simultaneous determination of p-arsanilic acid (p-ASA) and roxarsone in feed. 20% Methanol aqueous was used as extraction reagent, after preprocessing samples by ultrasonic oscillation, then injected into the chromatography Waters symmetry shield™ RP18 analytical column (150mm × 4.6mm, 5 μm), finally detected by an atomic fluorescence spectrometer. The calibration curves of analyses were linear over a range of concentrations (0.2–4mg L − 1) and the correlation coefficients were higher than 0.9990. The limits of detection were 0.2 mg L − 1. The method has been validated by linearity, precision and recovery. p-ASA and roxarsone in feed can be successfully and simultaneously determined using the developed method without a tedious pretreatment procedure.

Graphical abstract: Simultaneous determination of p-arsanilic acid and roxarsone in feed by liquid chromatography-hydride generation online coupled with atomic fluorescence spectrometry

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Publication details

The article was received on 25 Feb 2008, accepted on 17 Jun 2008 and first published on 03 Jul 2008


Article type: Paper
DOI: 10.1039/B803210F
J. Environ. Monit., 2008,10, 975-978

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    Simultaneous determination of p-arsanilic acid and roxarsone in feed by liquid chromatography-hydride generation online coupled with atomic fluorescence spectrometry

    J. Liu, H. Yu, H. Song, J. Qiu, F. Sun, P. Li and S. Yang, J. Environ. Monit., 2008, 10, 975
    DOI: 10.1039/B803210F

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