Issue 13, 2021

Direct amidation of acid fluorides using germanium amides

Abstract

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides Ph3GeNR2 convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group –NR2 to the carbonyl carbon, and so function as amidation reagents.

Graphical abstract: Direct amidation of acid fluorides using germanium amides

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2021
Accepted
19 Mar 2021
First published
22 Mar 2021

Dalton Trans., 2021,50, 4490-4493

Direct amidation of acid fluorides using germanium amides

A. Hayatifar, E. A. Elifritz, M. B. Bloom, K. M. Pixley, C. J. Fennell and C. S. Weinert, Dalton Trans., 2021, 50, 4490 DOI: 10.1039/D1DT00754H

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