Issue 13, 2021

Direct amidation of acid fluorides using germanium amides

Abstract

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method for their preparation is presented where germanium amides Ph3GeNR2 convert acid fluorides directly to amides. These germanium amides serve to abstract the fluorine atom of the acid fluoride and transfer their amide group –NR2 to the carbonyl carbon, and so function as amidation reagents.

Graphical abstract: Direct amidation of acid fluorides using germanium amides

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2021
Accepted
19 Mar 2021
First published
22 Mar 2021

Dalton Trans., 2021,50, 4490-4493

Author version available

Direct amidation of acid fluorides using germanium amides

A. Hayatifar, E. A. Elifritz, M. B. Bloom, K. M. Pixley, C. J. Fennell and C. S. Weinert, Dalton Trans., 2021, 50, 4490 DOI: 10.1039/D1DT00754H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements