Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Neazar E. Baghdadi; Benjamin P. Burke; Tahani Alresheedi; Shubhanchi Nigam; Abdu Saeed; Farooq Almutairi; Juozas Domarkas; Abid Khan; Stephen J. Archibald

doi:10.1039/D0DT02626C

Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles†

Neazar E. Baghdadi,

^ab Benjamin P. Burke,^c Tahani Alresheedi,^bcg Shubhanchi Nigam,^bc Abdu Saeed,

^d Farooq Almutairi,^bf Juozas Domarkas,^bc Abid Khan^ce and Stephen J. Archibald

*^bc

Author affiliations

* Corresponding authors

^a Centre of Nanotechnology, King Abdul-Aziz University, Jeddah, Saudi Arabia

^b Department of Chemistry, University of Hull, Cottingham Road, Hull, UK
E-mail: s.j.archibald@hull.ac.uk

^c Department of Biomedical Sciences and PET Research Centre, University of Hull Cottingham Road, Hull, UK

^d Department of Physics, Faculty of Science, King Abdul-Aziz University, Jeddah 21589, Saudi Arabia

^e Division of Pharmacy and Optometry, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

^f College of Applied Medical Sciences, University of Hafar Al-Batin, Hafar Al-Batin, Saudi Arabia

^g Department of Chemistry, College of Science and Art, Qassim University, Qassim, Saudi Arabia

Abstract

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

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DOI: https://doi.org/10.1039/D0DT02626C
Article type: Communication
Submitted: 25 Jul 2020
Accepted: 06 Jan 2021
First published: 19 Jan 2021
This article is Open Access

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Dalton Trans., 2021,50, 1599-1603

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Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

N. E. Baghdadi, B. P. Burke, T. Alresheedi, S. Nigam, A. Saeed, F. Almutairi, J. Domarkas, A. Khan and S. J. Archibald, Dalton Trans., 2021, 50, 1599 DOI: 10.1039/D0DT02626C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Dalton Transactions

Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles†

Abstract

Supplementary files

Article information

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Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

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