Issue 9, 2019

52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Abstract

trans-1,2-Diaminocyclohexane-N,N,N′,N′-tetraacetic acid (CDTA) labelled with a mixture of paramagnetic 55Mn(II) and β+-emitting 52gMn(II) offers access to bimodal Positron Emission Tomography/Magnetic Resonance (PET/MR) tracers. To enhance the number of NMR-active nuclei and simultaneously improve the longitudinal relaxivity r1, a complex composed of three CDTA units was designed. Accordingly, a functionalised tris-CDTA-1,3,5-tris-triazolobenzene was prepared and labelled with c.a. and n.c.a. 52gMn. Relaxivity measurements of the 55Mn-complex showed an enhancement of r1 of 144% in comparison to the Mn-CDTA monomer. Moreover, the trimer was equipped with an additional linker functionality suitable for conjugation with biomolecules, enabling interaction with specific molecular targets.

Graphical abstract: 52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

Article information

Article type
Paper
Submitted
19 Dec 2018
Accepted
05 Feb 2019
First published
06 Feb 2019

Dalton Trans., 2019,48, 3003-3008

52g/55Mn-Labelled CDTA-based trimeric complexes as novel bimodal PET/MR probes with high relaxivity

M. R. Brandt, C. Vanasschen, J. Ermert, H. H. Coenen and B. Neumaier, Dalton Trans., 2019, 48, 3003 DOI: 10.1039/C8DT04996C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements