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Issue 37, 2018
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Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

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Abstract

The two series of ruthenium–indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental–theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

Graphical abstract: Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

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Article information


Submitted
12 Jun 2018
Accepted
05 Jul 2018
First published
05 Jul 2018

Dalton Trans., 2018,47, 12838-12842
Article type
Communication

Ruthenium–indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

L. Chung, S. Ng, C. Yeung, H. Shek, S. Tse, H. Lo, S. Chan, M. Tse, S. Yiu and C. Wong, Dalton Trans., 2018, 47, 12838
DOI: 10.1039/C8DT02408A

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