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Issue 23, 2018
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Important cytotoxic and cytostatic effects of new copper(i)–phosphane compounds with N,N, N,O and N,S bidentate ligands

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Abstract

A family of six phosphane Cu(I) complexes bearing N,N, N,O and N,S bidentate ligands was synthesized. All the compounds were fully characterized by classical analytical and spectroscopic methods, and five of them were also characterized by X-ray diffraction studies. All the compounds exhibit high cytotoxicity against the human breast cancer cell line MCF7 with IC50 values far lower than those found for cisplatin, a current chemotherapeutic in clinical use. Compounds [1 with combining low line] and [3 with combining low line] induce cell cycle arrest in the G2/M phase and cell death by apoptosis. The cytotoxic and cytostatic effects of these compounds on MCF7 cells suggest that they are suitable for further in vivo studies with breast cancer models.

Graphical abstract: Important cytotoxic and cytostatic effects of new copper(i)–phosphane compounds with N,N, N,O and N,S bidentate ligands

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Article information


Submitted
25 Apr 2018
Accepted
17 May 2018
First published
22 May 2018

Dalton Trans., 2018,47, 7819-7829
Article type
Paper

Important cytotoxic and cytostatic effects of new copper(I)–phosphane compounds with N,N, N,O and N,S bidentate ligands

T. S. Morais, Y. Jousseaume, M. F. M. Piedade, C. Roma-Rodrigues, A. R. Fernandes, F. Marques, M. J. Villa de Brito and M. H. Garcia, Dalton Trans., 2018, 47, 7819
DOI: 10.1039/C8DT01653D

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