Issue 16, 2018

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Abstract

Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between log kRS and the thiol dissociation constants pKRSH is disclosed: log kRS = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS denotes the second-order rate constant of each thiolate towards the reduction of ormaplatin.

Graphical abstract: Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Supplementary files

Article information

Article type
Communication
Submitted
06 Mar 2018
Accepted
26 Mar 2018
First published
27 Mar 2018

Dalton Trans., 2018,47, 5548-5552

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

J. Dong, H. Tian, C. Song, T. Shi and L. I. Elding, Dalton Trans., 2018, 47, 5548 DOI: 10.1039/C8DT00852C

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