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Issue 36, 2017
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A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

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Abstract

Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(η6-p-cymene)Cl2] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule. Evaluation of the compounds on human ovarian cancer cells reveals synergistic enhancements in their antiproliferative activity relative to their bioactive organic and organometallic precursors.

Graphical abstract: A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

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Article information


Submitted
06 Jun 2017
Accepted
09 Jun 2017
First published
19 Jun 2017

Dalton Trans., 2017,46, 12001-12004
Article type
Communication

A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

L. Biancalana, L. K. Batchelor, A. De Palo, S. Zacchini, G. Pampaloni, P. J. Dyson and F. Marchetti, Dalton Trans., 2017, 46, 12001
DOI: 10.1039/C7DT02062G

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