Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 13, 2017
Previous Article Next Article

A metal ion regulated artificial metalloenzyme

Author affiliations

Abstract

Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the development of a metal ion regulated artificial metalloenzyme created by combining two anchoring strategies, covalent and supramolecular, for introducing a regulatory and a catalytic site, respectively. This artificial metalloenzyme is activated in the presence of Fe2+ ions, but only marginally in the presence of Zn2+.

Graphical abstract: A metal ion regulated artificial metalloenzyme

Back to tab navigation

Supplementary files

Article information


Submitted
13 Feb 2017
Accepted
27 Feb 2017
First published
27 Feb 2017

Dalton Trans., 2017,46, 4325-4330
Article type
Paper

A metal ion regulated artificial metalloenzyme

M. Bersellini and G. Roelfes, Dalton Trans., 2017, 46, 4325
DOI: 10.1039/C7DT00533D

Social activity

Search articles by author

Spotlight

Advertisements