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Issue 13, 2017
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A metal ion regulated artificial metalloenzyme

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Regulation of enzyme activity is essential in living cells. The rapidly increasing number of designer enzymes with new-to-nature activities makes it necessary to develop novel strategies for controlling their catalytic activity. Here we present the development of a metal ion regulated artificial metalloenzyme created by combining two anchoring strategies, covalent and supramolecular, for introducing a regulatory and a catalytic site, respectively. This artificial metalloenzyme is activated in the presence of Fe2+ ions, but only marginally in the presence of Zn2+.

Graphical abstract: A metal ion regulated artificial metalloenzyme

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Article information

13 Feb 2017
27 Feb 2017
First published
27 Feb 2017

Dalton Trans., 2017,46, 4325-4330
Article type

A metal ion regulated artificial metalloenzyme

M. Bersellini and G. Roelfes, Dalton Trans., 2017, 46, 4325
DOI: 10.1039/C7DT00533D

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