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Issue 33, 2016
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An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

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Abstract

An acetal-linked self-quenched zinc(II) phthalocyanine tetramer has been prepared. In an acidic environment in phosphate buffered saline or inside tumour cells, the phthalocyanine units of the tetramer are separated thereby restoring the fluorescence emission and singlet oxygen production. This response enables this compound to serve as a promising activatable photosensitiser for photodynamic therapy.

Graphical abstract: An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

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Article information


Submitted
08 Jun 2016
Accepted
28 Jun 2016
First published
29 Jun 2016

Dalton Trans., 2016,45, 13021-13024
Article type
Communication

An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy

S. Y. S. Chow, P. Lo and D. K. P. Ng, Dalton Trans., 2016, 45, 13021
DOI: 10.1039/C6DT02283A

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