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Issue 33, 2016
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Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

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Abstract

We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.

Graphical abstract: Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

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Supplementary files

Article information


Submitted
09 Apr 2016
Accepted
06 May 2016
First published
18 May 2016

This article is Open Access

Dalton Trans., 2016,45, 13034-13037
Article type
Communication
Author version available

Spin-labelled photo-cytotoxic diazido platinum(IV) anticancer complex

V. Venkatesh, C. J. Wedge, I. Romero-Canelón, A. Habtemariam and P. J. Sadler, Dalton Trans., 2016, 45, 13034
DOI: 10.1039/C6DT01382A

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