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Issue 13, 2016
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Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

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Abstract

Two series of ferrocenyl- and aryl-derived cyclopalladated organosilane thiosemicarbazone complexes were synthesised via C–H bond activation. Selected compounds were evaluated for in vitro antiplasmodial activity against the chloroquine-sensitive (NF54) and chloroquine-resistant (Dd2) strains of the human malaria parasite Plasmodium falciparum. Cyclopalladation of the thiosemicarbazones resulted in antiplasmodial activities in the low micromolar range.

Graphical abstract: Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

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Publication details

The article was received on 17 Dec 2015, accepted on 16 Feb 2016 and first published on 25 Feb 2016


Article type: Paper
DOI: 10.1039/C5DT04918K
Citation: Dalton Trans., 2016,45, 5514-5520
  • Open access: Creative Commons BY-NC license
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    Cyclopalladated organosilane–tethered thiosemicarbazones: novel strategies for improving antiplasmodial activity

    M. Adams, L. Barnard, C. de Kock, P. J. Smith, L. Wiesner, K. Chibale and G. S. Smith, Dalton Trans., 2016, 45, 5514
    DOI: 10.1039/C5DT04918K

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