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Issue 2, 2016
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Luminescent bioactive NHC–metal complexes to bring light into cells

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Abstract

Organometallic complexes are mostly used in catalytic applications and nowadays they are attracting more and more attention for biomedical applications. Until the last decade, research in the latter area was focused on screening of complexes against cancer cell lines, bacteria or parasites. For a couple of years mechanistic studies have helped in elucidating the mode of action of such complexes, one of the applied methods consists of studying cell uptake and intracellular distribution of luminescent bioactive complexes, in order to identify the main targets. This perspective summarizes the results obtained with luminescent bioactive NHC–metal complexes in this field of research.

Graphical abstract: Luminescent bioactive NHC–metal complexes to bring light into cells

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Article information


Submitted
06 Oct 2015
Accepted
17 Nov 2015
First published
19 Nov 2015

Dalton Trans., 2016,45, 440-447
Article type
Perspective
Author version available

Luminescent bioactive NHC–metal complexes to bring light into cells

C. Hemmert and H. Gornitzka, Dalton Trans., 2016, 45, 440
DOI: 10.1039/C5DT03904E

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