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Issue 26, 2015
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X-ray structurally characterized sensors for ratiometric detection of Zn2+ and Al3+ in human breast cancer cells (MCF7): development of a binary logic gate as a molecular switch

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Abstract

A very simple molecule derived from salicylaldehyde and N-phenyl ethylenediamine (L1) functions as dual-mode ratiometric fluorescence “turn on” sensors for Zn2+ and Al3+ at two different wavelengths. The sensing is based on the combined effect of inhibition of excited-state intra-molecular proton transfer (ESIPT), CH[double bond, length as m-dash]N isomerization and chelation-enhanced fluorescence (CHEF). Moreover, the [L1–Zn2+] system functions as a better Al3+ sensor where Al3+ ratiometrically displaces Zn2+ from the [L1–Zn2+] complex. Emission wavelength dependent differentiation of Zn2+ and Al3+ using L1 allows us to develop a binary logic gate that functions as a molecular switch. L1 efficiently detects Zn2+ and Al3+ in human breast cancer cells (MCF7) while the [L1–Zn2+] complex specifically detects Al3+ in the said cells.

Graphical abstract: X-ray structurally characterized sensors for ratiometric detection of Zn2+ and Al3+ in human breast cancer cells (MCF7): development of a binary logic gate as a molecular switch

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Supplementary files

Article information


Submitted
04 Apr 2015
Accepted
26 May 2015
First published
27 May 2015

Dalton Trans., 2015,44, 11797-11804
Article type
Paper

X-ray structurally characterized sensors for ratiometric detection of Zn2+ and Al3+ in human breast cancer cells (MCF7): development of a binary logic gate as a molecular switch

A. Ghosh and D. Das, Dalton Trans., 2015, 44, 11797
DOI: 10.1039/C5DT01303H

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