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Issue 16, 2015
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Fine control on the photochemical and photobiological properties of Ru(II) arene complexes

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Abstract

A series of six Ru(arene) complexes, [(η6-p-cymene)Ru(dpb)(py-R)]2+ (1–6, dpb = 2,3-bis(2-pyridyl)benzoquinoxaline, py-R = 4-substituted pyridine, R = N(CH3)2, NH2, OCH3, H, COOCH3 and NO2), were synthesized and their photochemical and photobiological properties were compared in detail. The electron push/pull character of the R groups has a significant impact on both ligand photodissociation and 1O2 generation of the complexes. The photoinduced DNA covalent binding capabilities increase from 1 to 6 under both aerobic and anaerobic conditions, and DNA photocleavage occurs simultaneously in aerobic environments. 4 has the most potent phototoxicity against human lung carcinoma A549 cells among the examined complexes. The substituent effect may be ascribed to the influences of the R groups on the energy levels of 3MC and 3MLCT states as well as the energy gaps between 3MC, 3MLCT and dpb-based 3IL states. Similar chemical modification on bidentate and arene ligands or other sites of the pyridine ligand may lead to more efficient agents with PDT and/or PACT activities.

Graphical abstract: Fine control on the photochemical and photobiological properties of Ru(ii) arene complexes

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Publication details

The article was received on 09 Mar 2015, accepted on 12 Mar 2015 and first published on 23 Mar 2015


Article type: Paper
DOI: 10.1039/C5DT00939A
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Citation: Dalton Trans., 2015,44, 7347-7354

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    Fine control on the photochemical and photobiological properties of Ru(II) arene complexes

    Y. Chen, W. Lei, Y. Hou, C. Li, G. Jiang, B. Zhang, Q. Zhou and X. Wang, Dalton Trans., 2015, 44, 7347
    DOI: 10.1039/C5DT00939A

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