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Issue 8, 2015
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Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA

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Abstract

The ability of mononucleating and dinucleating macrocylic polyamines and their novel nickel, copper and zinc complexes to induce the left-handed form of poly d(GC) was evaluated. The influence of the nuclearity, the presence or absence of metals ions, the linker length in the case of dinucleating ligands and the metal ion was determined. Almost all dinuclear metal complexes efficiently induced Z-DNA, the zinc ones being the least and the copper ones the most efficient ones. Additionally, the X-ray structures of three dinuclear metal complexes and one partially protonated ligand could be determined.

Graphical abstract: Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA

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Article information


Submitted
04 Sep 2014
Accepted
04 Dec 2014
First published
05 Dec 2014

This article is Open Access

Dalton Trans., 2015,44, 3664-3672
Article type
Paper
Author version available

Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA

A. Medina-Molner, M. Rohner, D. Pandiarajan and B. Spingler, Dalton Trans., 2015, 44, 3664
DOI: 10.1039/C4DT02713B

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