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Issue 32, 2014
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NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

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Abstract

We report here that the established anticancer ruthenium(III) complex NAMI-A induces potent and selective cytotoxic effects in a few leukaemia cell lines. These results sound very surprising after 20 years of intense studies on NAMI-A, commonly considered as a “non-cytotoxic” antimetastatic agent. In addition, evidence is given for selective inhibition of KCa 3.1 channels. The implications of these findings are discussed.

Graphical abstract: NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

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Supplementary files

Article information


Submitted
07 May 2014
Accepted
16 Jun 2014
First published
16 Jun 2014

Dalton Trans., 2014,43, 12150-12155
Article type
Communication
Author version available

NAMI-A is highly cytotoxic toward leukaemia cell lines: evidence of inhibition of KCa 3.1 channels

S. Pillozzi, L. Gasparoli, M. Stefanini, M. Ristori, M. D'Amico, E. Alessio, F. Scaletti, A. Becchetti, A. Arcangeli and L. Messori, Dalton Trans., 2014, 43, 12150
DOI: 10.1039/C4DT01356E

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