Issue 41, 2013
From the journal:

Dalton Transactions

Structures and anti-cancer properties of two binuclear copper complexes†

Xiu Ying Qin,ab   Li Cong Yang,a   Fang Ling Le,a   Qian Qian Yu,a   Dong Dong Sun,a   Ya Nan Liuc  and  Jie Liu*a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou 510632, China
E-mail: tliuliu@jnu.edu.cn
Fax: +86 20 85221263
Tel: +86 20 85220223

b College of Pharmacy, Guilin Medical University, Guilin, China

c Department of Biology, The Chinese University of Hong Kong, Hong Kong, China

Abstract

The crystals of two binuclear copper-based complexes were obtained. One complex can remarkably induce apoptosis and inhibit angiogenesis to mediate tumour growth at a greater extent. Furthermore, this complex showed a strong energy-dependent and non-endocytotic uptake and exhibited multiple anti-cancer functions by inhibiting the expressions of p-Akt and p-Erk1/2 proteins and by decreasing the levels of reactive oxygen species.

Graphical abstract: Structures and anti-cancer properties of two binuclear copper complexes

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Article information

DOI
https://doi.org/10.1039/C3DT51548F
Article type
Communication
Submitted
11 Jun 2013
Accepted
23 Aug 2013
First published
23 Aug 2013

Dalton Trans., 2013,42, 14681-14684

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Structures and anti-cancer properties of two binuclear copper complexes

X. Y. Qin, L. C. Yang, F. L. Le, Q. Q. Yu, D. D. Sun, Y. N. Liu and J. Liu, Dalton Trans., 2013, 42, 14681 DOI: 10.1039/C3DT51548F

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