Issue 27, 2013

Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging

Abstract

Nearly monodispersed yolk-type Au@Fe3O4@C nanospheres with hollow cores of 50 nm in diameter were prepared through coating Au@SiO2 nanoparticles with Fe3O4@C double layers, followed by dissolving SiO2. The cytotoxicity of the nanospheres was evaluated by MTT assay, demonstrating a high biocompatibility. The yolk-type nanospheres show a high DOX loading content of 1237 mg g−1. The coexistence of Fe3O4 and Au also makes the nanospheres as dual probes for MR imaging with a specific relaxivity (r2*) of 384.38 mM−1 s−1 and optical fluorescence imaging using a near-infrared (NIR) excitation.

Graphical abstract: Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging

Supplementary files

Article information

Article type
Paper
Submitted
24 Mar 2013
Accepted
02 May 2013
First published
02 May 2013

Dalton Trans., 2013,42, 9906-9913

Yolk-type Au@Fe3O4@C nanospheres for drug delivery, MRI and two-photon fluorescence imaging

Y. Zhou, H. Wang, M. Gong, Z. Sun, K. Cheng, X. Kong, Z. Guo and Q. Chen, Dalton Trans., 2013, 42, 9906 DOI: 10.1039/C3DT50789K

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