Issue 2, 2013

Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

Abstract

Sixteen arene–Ru based molecular-rectangles were self-assembled in high yields by the equimolar mixing of arene–Ru acceptors (Aa–Ad) with various azopyridyl ligands (1,2-di(pyridyl-4yl)diazene (L1), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L2), 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (L3), 1,2-bis(pyridin-4-ylmethylene)hydrazine (L4)) in nitromethane–methanol solutions. These new molecular-rectangles were fully characterized by a host of analytical techniques including elemental analysis, 1H and 13C NMR and HR-ESI-MS. The solid-state structures of two molecular-rectangles (1b and 4d) were determined by single crystal X-ray diffraction data. UV-visible and fluorescence studies were also carried out for the entire suite of rectangles. As with recent studies of similar arene–Ru complexes, the anti-proliferative activities of these complexes were evaluated against SK-hep-1 (liver cancer) and A-549 (lung cancer) human cancer lines. Additionally, the cellular pharmacology and intracellular localizations in AGS (gastric cancer) human cancer cells were determined for selected complexes (1c, 1d and 4c) by apoptosis and fluorescence microscopy studies. These studies confirm that arene–Ru molecular-rectangles inhibit cell cycle progression to the G0 phase, in contrast to that of cisplatin which arrests cell growth in the G2 phase.

Graphical abstract: Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

Supplementary files

Article information

Article type
Paper
Submitted
09 May 2012
Accepted
11 Sep 2012
First published
16 Oct 2012

Dalton Trans., 2013,42, 466-475

Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity

V. Vajpayee, S. Lee, S. Kim, S. C. Kang, T. R. Cook, H. Kim, D. W. Kim, S. Verma, M. S. Lah, I. S. Kim, M. Wang, P. J. Stang and K. Chi, Dalton Trans., 2013, 42, 466 DOI: 10.1039/C2DT31014G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements