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Issue 29, 2012
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Effect of chelating ring size in catalytic ketone hydrogenation: facile synthesis of ruthenium(ii) precatalysts containing an N-heterocyclic carbene with a primary amine donor for ketone hydrogenation and a DFT study of mechanisms

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Abstract

A half-sandwich ruthenium(II) complex, [Ru(η6-p-cymene)(C–NH2)Cl]PF6 (4·PF6), containing an N-heterocyclic carbene (NHC) with a primary amine donor (C–NH2) which chelates through the carbene carbon and the amine nitrogen to form a 6-membered ring was synthesized in a one-pot reaction starting from a primary-amine functionalized imidazolium salt 2. Complex 4·PF6 catalyzed the hydrogenation of ketones using 2-propanol or H2 as the reductant. A maximum turnover frequency of 1062 h−1 and a turnover number of 1140 at 5 h were achieved for the transfer hydrogenation of 3′-chloroacetophenone in 2-propanol at 75 °C. A cationic hydride–amine complex 5, [Ru(η6-p-cymene)(C–NH2)H]PF6, was synthesized, and this reacted very slowly with acetophenone unless first activated by an alkoxide base. Computational studies by DFT methods suggested that the poor reactivity of the hydride–amine complex 5 was attributed to a large barrier for the transfer of its H+/H couple to a ketone for bifunctional catalysis. An inner-sphere mechanism, which involves a decoordinated amine group of the C–NH2 ligand, was computed to be a feasible energetic pathway in comparison to the computed outer-sphere bifunctional mechanism. This explains the catalytic activity and selectivity that is observed for the newly synthesized ruthenium(II) catalysts.

Graphical abstract: Effect of chelating ring size in catalytic ketone hydrogenation: facile synthesis of ruthenium(ii) precatalysts containing an N-heterocyclic carbene with a primary amine donor for ketone hydrogenation and a DFT study of mechanisms

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Supplementary files

Article information


Submitted
07 May 2012
Accepted
22 May 2012
First published
23 May 2012

Dalton Trans., 2012,41, 8797-8808
Article type
Paper

Effect of chelating ring size in catalytic ketone hydrogenation: facile synthesis of ruthenium(II) precatalysts containing an N-heterocyclic carbene with a primary amine donor for ketone hydrogenation and a DFT study of mechanisms

H. Ohara, W. W. N. O, A. J. Lough and R. H. Morris, Dalton Trans., 2012, 41, 8797
DOI: 10.1039/C2DT30994G

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