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Issue 26, 2012
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A responsive particulate MRI contrast agent for copper(i): a cautionary tale

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A responsive MION-based MRI contrast agent for the detection of copper(I) is presented. Induced agglomeration of azide and acetylene-functionalized magnetite nanoparticles via Cu(I)-catalysed Huisgen cycloaddition leads to significant decrease in longitudinal relaxivity due to the slow exchange of water molecules trapped within the cluster with bulk solvent. Agglomeration leads to an initial two-fold increase followed by a sharp and almost complete loss in transverse relaxivity for clusters larger than 200 nm in size. The decrease in r2 for clusters reaching the static dephasing regime has two significant implications for particulate responsive MRI contrast agents. First, the maximum increase in r2 is barely two-fold, second, since r2 does not increase continuously with increasing cluster size, the r1/r2 ratio cannot be used to determine the concentration of an analyte ratiometrically.

Graphical abstract: A responsive particulate MRI contrast agent for copper(i): a cautionary tale

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Article information

21 Feb 2012
17 Apr 2012
First published
20 Apr 2012

Dalton Trans., 2012,41, 8039-8046
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A responsive particulate MRI contrast agent for copper(I): a cautionary tale

E. D. Smolensky, M. Marjańska and V. C. Pierre, Dalton Trans., 2012, 41, 8039
DOI: 10.1039/C2DT30416C

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