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Issue 31, 2012
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Phosphine–phosphite ligands: chelate ring size vs. activity and enantioselectivity relationships in asymmetric hydrogenation

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Abstract

A series of new phosphine–phosphite ligands P(C)nOP (n = 1–4) have been synthesized and used for rhodium-catalyzed asymmetric hydrogenation of prochiral olefins in order to study the effect of the chelate ring size. Excellent ees (up to 97.5%) were obtained in the hydrogenation of dimethyl itaconate and an increase of activity and enantioselectivity was observed in the hydrogenation of (Z)-α-acetamidocinnamic acid methyl ester with the increasing length of the backbone of the ligands.

Graphical abstract: Phosphine–phosphite ligands: chelate ring size vs. activity and enantioselectivity relationships in asymmetric hydrogenation

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Article information


Submitted
17 Feb 2012
Accepted
15 Jun 2012
First published
04 Jul 2012

Dalton Trans., 2012,41, 9493-9502
Article type
Paper

Phosphine–phosphite ligands: chelate ring size vs. activity and enantioselectivity relationships in asymmetric hydrogenation

G. Farkas, S. Balogh, J. Madarász, Á. Szöllősy, F. Darvas, L. Ürge, M. Gouygou and J. Bakos, Dalton Trans., 2012, 41, 9493
DOI: 10.1039/C2DT30386H

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